import win32event import win32security evt = win32event.CreateEvent(None, 0, 0, None) win32security.LsaRegisterPolicyChangeNotification( win32security.PolicyNotifyAuditEventsInformation, evt ) print("Waiting for you change Audit policy in Management console ...") ret_code = win32event.WaitForSingleObject(evt, 1000000000) ## should come back when you change Audit policy in Management console ... print(ret_code) win32security.LsaUnregisterPolicyChangeNotification( win32security.PolicyNotifyAuditEventsInformation, evt )